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Species affected: Cats
Background: This disorder is almost never seen in dogs—and certainly not from the same cause as in cats. Cats that are overweight and suddenly stop eating undergo hepatic metabolic changes that may lead to the body preferentially metabolizing body fat; this leads to continued anorexia.
Symptoms: The onset is rapid and characterized by vomiting, anorexia, depression and electrolyte imbalances.
Diagnostics: Rapidly confirmed by blood tests.
Special Notes:
For obese cats, fasting or even markedly decreased appetite for 3 days often results in hepatic lipidosis. Thinner cats can fast for longer periods of time, but are still in danger.
Principles for Supplementation: The therapeutic goal is to support the urea cycle while forcing food (usually via esophageal or gastric tube). Carnitine helps oxidize fatty acids in the liver cell; arginine may be deficient in these cats. Fish oil, zinc and antioxidants also support the urea cycle. Force feeding may have to continue for as long as a month.


Formulas: Dosage: Mechanism/Purpose:


Cats: 1 capsule sid

Helps oxidize fatty acids.


Cats: ½ capsule sid

Anti-inflammatory and antioxidant. Hepatoprotective effects are due in part to direct free radical scavenging; but curcumin also enhances the body's natural antioxidant system, which increases glutathione levels, thereby aiding in hepatic detoxification and inhibiting nitrosamine formation.


Cats: 1capsule bid

Balanced formula supports the hepatic detoxification pathways.

Liver Protect27

Cats: ½-1 scoop sid
(mixed with food)

Cleanses and regenerates the liver. Protects liver and improves liver function; antioxidant, antiperoxidative, and anti-inflammatory effects; protects against effects of prednisone;
promotes liver regeneration.

Manganese Citrate12

Cats: ¼ capsule bid

Increases level of SOD; activator of many enzymes and constituents of some metalloenzymes; involved in bone and cartilage development, reproduction and lipid metabolism; antacids can inhibit absorption.

Milk Thistle27

1 capsule per 20 lb bid or 1 scoop per 20 lb bid

Supports normal detoxification process. Protects the liver.


Cats: ¼ tablet sid

Combination of antioxidants and herbs that support liver detoxification function and contribute to the formation of superoxide dismutase.


Cats: ¼ capsule bid

Source of arginine; supports the urea cycle.

Pyridoxal 5’-

Cats: ¼ capsule sid

Pyridoxal-5’-phosphate is the active form of vitamin B6. Animals with compromised liver function may have a problem converting B6 to this active form.

Omega PlusVET12

Cats: 1 gelcap sid


Small Animal

Cats: 1 capsule sid

Antioxidant with potent nutraceutical and plant-based antioxidants.


Cats: 2 bid of the bite-size

Designed to support liver health, methylation, and detoxification functions.

Section 1 - Canine and Feline Index of Pages


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